Tysabri Rebound Study

Most of the research regarding Tysabri safety has focused on the drug causing increased risk of death from the deadly brain infection PML. Something that the drug's creator, Lawrence Steinman, warned about more than a decade ago.

What's been largely glossed over are cases like mine, where blood tests identify the risk, but removal of the drug sets up the patient for a horrific MS rebound attack. The industry seems to think that by preventing rapid death by PML, these tests represent an acceptable safety protocol for using the dangerous drug. As someone who was crippled and almost killed by such a relapse, I could not disagree more.

In this under-publicized study, 52.9% of patients taken off of Tysabri showed unusually high MRI inflammation within a year, and 9% showed severe relapses 3 to 9 months after drug cessation.

Abnormal inflammatory activity returns after natalizumab cessation in multiple sclerosis.

http://www.ncbi.nlm.nih.gov/pubmed/24876183